Wound healing
Presentation
•
Biology
•
Professional Development
•
Practice Problem
•
Hard
harrison hunter
Used 1+ times
FREE Resource
10 Slides • 5 Questions
1
Tissue Repair, Remodeling, and Scarring
Harrison
2
Case relevance
Scott had an abscess that could have potentially become an open wound.
3
Objective
Review this old info that may come up on our exam.
4
Multiple Choice
List the layers of the skin from outermost layer to innermost.
5
6
Multiple Choice
What layer of the skin needs to be damaged in order for a scar to form?
Hypodermis
Subcutaneous Tissue
7
Lay down layers of collagen, Elastin, and GAGs
Migrate to areas of tissue damage
Fibroblasts
Secrete Alpha-Smooth muscle actin
Induced by TGF-beta1
Myofibroblasts
Major cell types involved
8
9
10
11
Multiple Choice
Which type of intention would this be healed by?
Primary
Secondary
Tertiaty
12
Cytokines of Wound Healing
FGF-angiogenesis
TGF-Beta-fibrosis, angiogenesis, Alpha-SMA stimulation
VEGF- angiogenesis
PDGF- fibroblast growth, vascular remodeling
Metalloproteinases- tissue remodeling
EGF- stimulates cell growth
13
Multiple Choice
What role does TGF-β1 play in the differentiation of fibroblasts into myofibroblasts?
Inhibits the expression of α-smooth muscle actin
Stimulates the synthesis of extracellular matrix proteins and promotes α-smooth muscle actin expression
Enhances the activity of collagenases and elastases
14
Multiple Select
Which cytokines stimulate angiogenesis? (Multiple answers)
FGF
TGF-Beta
VEGF
PDGF
15
Resources
Northwestern Medicine. What Makes a Scar? Northwestern Medicine HealthBeat. Published March 2024. Accessed August 21, 2024. https://www.nm.org/healthbeat/healthy-tips/emotional-health/what-makes-a-
Darby IA, Desmoulière A. Scar Formation: Cellular Mechanisms. 2020 Dec 8. In: Téot L, Mustoe TA, Middelkoop E, et al., editors. Textbook on Scar Management: State of the Art Management and Emerging Technologies [Internet]. Cham (CH): Springer; 2020. Chapter 3. Available from: https://www.ncbi.nlm.nih.gov/books/NBK586083/#doi: 10.1007/978-3-030-44766-3_3
First Aid (2023 pg 212)
Tissue Repair, Remodeling, and Scarring
Harrison
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