MRTS 2231 Ch 11

The lymphatic system is a collection of organs involved in the production, maturation, and harboring of white blood cells called lymphocytes. It also includes a network of vessels that transport or filter the fluid known as lymph in which lymphocytes circulate.

• Transport of body fluid to the bloodstream

• Help to protect body against disease causing agents

• Absorption of fats from the small intestine

The lymphatic vessels form a transportation network similar in many respects to the blood vessels of the cardiovascular system. However, unlike the cardiovascular system, the lymphatic system is not a closed system. Instead, lymphatic vessels carry lymph in a single direction, always toward the upper chest, where the lymph empties from lymphatic vessels into blood vessels.

Once tissue (insterstitial) fluid enters the lymphatic vessels, it is called lymph. Lymph is very similar in composition to blood plasma. Besides water, lymph may contain proteins, waste products, cellular debris, and pathogens. It also contains numerous white blood cells, especially the subset of white blood cells known as lymphocytes.

The lymph that enters lymph capillaries in tissues is transported through the lymphatic vessel network to two large lymphatic ducts in the upper chest. Right lymphatic duct and the left lymphatic or thoracic duct.

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​R- drains right upper quadrant

​L- drains left upper quadrant and both lower quadrants

From there, the lymph flows into two major veins (called subclavian veins) of the cardiovascular system. Unlike blood, lymph is not pumped through its network of vessels. Instead, lymph moves through lymphatic vessels via a combination of contractions of the vessels themselves and forces applied to the vessels externally by skeletal muscles.

​R- right subclavian or right brachiocephalic

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​L- left subclavian or left brachiocephalic

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​Cisterna chyli is a collecting place for lymph before dumping into the thoracic duct

Just like veins, your lymphatics have three layers

• ​intima

• ​media

• ​adventitia

Lymphatic vessels called lacteals are present in the lining of the gastrointestinal tract, mainly in the small intestine. Each tiny villus in the lining of the small intestine has an internal bed of capillaries and lacteals. The capillaries absorb most nutrients from the digestion of food into the blood. The lacteals absorb mainly fatty acids from lipid...

digestion into the lymph, forming a fatty-acid-enriched fluid called chyle. Vessels of the lymphatic network then transport chyle from the small intestine to the main lymphatic ducts in the chest from which it drains into the blood circulation. The nutrients in chyle then circulate in the blood to the liver, where they are processed along with the other nutrients that reach the liver directly via the bloodstream.

The primary function of the lymphatic system is host defense as part of the immune system. This function of the lymphatic system is centered on the production, maturation, and circulation of lymphocytes. Lymphocytes are leukocytes that are involved in the adaptive immune system. They are responsible for the recognition of, and tailored defense against, specific pathogens or tumor cells.

Lymphocytes may also create a lasting memory of pathogens so they can be attacked quickly and strongly if they ever invade the body again. In this way, lymphocytes bring about long-lasting immunity to specific pathogens.

 In this maturation process, they “learn” to distinguish self from non-self. Only those lymphocytes that successfully complete this maturation process go on to actually fight infections by pathogens.

The tonsils, spleen, and lymph nodes are referred to as secondary lymphoid organs. These organs do not produce or mature lymphocytes. Instead, they filter lymph and store lymphocytes. It is in these secondary lymphoid organs that pathogens (or their antigens) activate lymphocytes and initiate adaptive immune responses.

Activation leads to the cloning of pathogen-specific lymphocytes, which then circulate between the lymphatic system and the blood, searching for and destroying their specific pathogens by producing antibodies against them.