1. DRUGS ACTING ON ENDOCRINE SYSTEM
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Chemistry
•
University
•
Hard
TITIKSH SSRCP
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56 Slides • 17 Questions
1
Drugs ACTING ON ENDOCRINE GLAND
by TITIKSH
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3
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Multiple Choice
Steroids contains following numbers of rings
2
3
4
5
7
8
9
Multiple Choice
The basic skeleton of steroid is named as
1,3 cyclopentanophenanthrene
1,2 cyclopentanophenanthrene
1,2 cyclopentanoanthracene
1,3 cyclopentanoanthracene
10
11
Multiple Choice
In the nomenclature of steroids α (alpha) substituents are located on
Above the plane
Below the plane
in Plane
none of above
12
Multiple Choice
In the nomenclature of steroids BETA substituents are located on
Above the plane
Below the plane
in Plane
none of above
13
Multiple Choice
Following are basic skeletons of steroids except
Gonane
Estrane
Androstane
Nonane
14
Multiple Choice
Chiral centre in 5α cholestane are
6
5
4
3
15
Multiple Choice
Δ sign in name of steroid indicates
Double bond
Triple bond
Single bond
Both A and B
16
Multiple Choice
Nor in the name of steroid indicate
Presence of Methyl group
Absence of methyl group
presence of double bond
Absence of double bond
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Multiple Choice
What is precursor for synthesis of sex hormone
Lipids
Cholesterol
Amino acids
Carbohydrates
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Multiple Choice
find the odd from the options given below
Diethylstibetrol
ethynylestradiol
Estrone
Mestranol
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Fill in the Blanks
Type answer...
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Multiple Choice
prodrugs of estrogens can be made by making substitution at following positions
3,17
3,16
5,17
16,17
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Fill in the Blanks
Type answer...
60
t
These are contraindicated along with nitrates due to hypotension
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Fill in the Blanks
Type answer...
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63
Multiple Choice
one of following heterocyclic ring is not the part of structure of Tadalafil
piperidine
piprazine
Indole
imidazole
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T3
T4
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3-methyl-1H-imidazole-2-thione
3-methyl-1H-imidazole-2-thione
6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
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Multiple Choice
The structure of methimazole has following heterocycle
Imidazole
Pyrazole
PYRIDINE
PYRIMIDINE
71
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
3-methyl-1H-imidazole-2-thione
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Propyl thiouracil
6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
Propylthiouracil is a thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4).
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Multiple Choice
Propylthiouracil has one of following heterocycle
Urea
Pyrimidine
Purine
THIAZOLE
Drugs ACTING ON ENDOCRINE GLAND
by TITIKSH
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