Antidepressants
Presentation
•
Science
•
Professional Development
•
Medium
Elsa Mohamed
Used 15+ times
FREE Resource
41 Slides • 6 Questions
1
2
Objectives:
•Basis for the use of the various types of anti-depressants
•Mechanisms by which these drugs act and their potential adverse effects
•Relevant pharmacokinetic aspects to the therapeutic uses of these drugs
3
4
Different depressive symptoms reflect dysfunction in different neurotransmitter systems, which is why antidepressants with different mechanisms produce different clinical effects.
5
6
7
8
9
10
11
12
13
14
15
Autoreceptors & heteroreceptors
Autoreceptors & heteroreceptors in CNS functions as negative feedback mechanisms
Response to AD drugs (eg. SSRIs) by 5-HT1A autoreceptors stimulation: initial reduce 5-HT release, subsequently desensitize by receptor internalisation & restores/enhanced 5-HT release
α2 autoreceptors modulate NA release
16
Multiple Choice
These are mechanisms of antidepressant drug actions EXCEPT
alpha-2 autoreceptor blockade
serotonin 5-HT1A autoreceptor blockade
serotonin 5-HT1A agonist
Serotonin reuptake transporter blockade
serotonin 5-HT2C blockade
17
Other examples: Citalopram, escitalopram, paroxetine
18
19
20
This makes the classical triad
21
22
Open Ended
List 3 SSRI drugs
23
24
Open Ended
List the triad of serotonin syndrome
25
26
27
28
Multiple Choice
A 55-year-old lady with type 2 diabetes mellitus has been having chronic pains over her hands and feet. She described the pain as being burning in nature and is worse at night. The pain is not relieved by paracetamol or ponstan. This has made her depressed. Which of the following drugs may be used to treat this lady?
Duloxetine
Mirtazapine
Bupropion
Moclobemide
29
Pain can be modulated via descending pathway
ADs which act by increasing NA (and 5-HT) such as duloxetine and amitriptyline works by increasing NA in the dorsal horn
ADs and neuropathic pain
30
31
Multiple Select
Weight gain seen with mirtazapine treatment is most likely due to effects on this/these receptor(s) (can be more than 1 answer):
5-HT2A
5-HT2C
5-HT1A
5-HT3
H1
32
33
34
35
36
37
38
39
Multiple Choice
The tyramine-reaction seen with MAOI-tyramine rich food is due to
centrally acting tyramine effect
tyramine effect on peripheral α and β receptors
40
41
42
43
Add agomelatine & vortioxetine to the list!
44
45
46
THANK YOU!
47
Show answer
Auto Play
Slide 1 / 47
SLIDE
Similar Resources on Wayground
41 questions
Formal Statements of Human Rights
Presentation
•
11th - 12th Grade
41 questions
Cisco CyberOps Review 1
Presentation
•
Professional Development
47 questions
Unit 4A Homeostasis & Portfolio
Presentation
•
KG - University
44 questions
489-Revision
Presentation
•
KG
35 questions
Ch 9 Blood, Lymph, & Immunity Pathology
Presentation
•
University
46 questions
Pharm
Presentation
•
12th Grade
36 questions
Psychology Personality
Presentation
•
12th Grade
36 questions
Unit 23 Compressors Slides (CRF)-Mr.Graham
Presentation
•
University
Popular Resources on Wayground
24 questions
PBIS-HGMS Day 10
Quiz
•
6th - 8th Grade
10 questions
HCS SCI 03 Summer School Review 3
Quiz
•
3rd Grade
11 questions
Home Scope
Quiz
•
7th - 8th Grade
15 questions
HCS SCI 05 Summer School Assessment 3 Review
Quiz
•
5th Grade
35 questions
Lufkin Road Middle School Student Handbook & Policies Assessment
Quiz
•
7th Grade
18 questions
Geo 11.3 Area of Circles and Sectors
Quiz
•
9th - 11th Grade