Clinicomm set 2

In a hospital outbreak investigation of carbapenem-resistant Klebsiella pneumoniae, which study design best determines the risk factors for colonization among ICU patients while controlling for confounders?

During an RCT assessing a new rapid sepsis screening tool, interim analysis shows borderline benefit (p=0.049). Which approach avoids inflated Type I error?

Non-inferiority trial of two HAP regimens: CI for difference in cure rates lies entirely within the non-inferiority margin. Interpretation?

Early discharge protocol using troponin: NPV is 99% in low-risk chest pain. What most affects NPV?

Hospital hand hygiene observations: Hawthorne effect will most likely…

Oncology survival analysis violates proportional hazards. Best alternative?

ICU sepsis bundle trial: RR=0.85 (95% CI: 0.60-1.02).

Retrospective decade-long liver transplant outcomes at a tertiary center: most likely bias?

Time-series of monthly CAUTI rates before/after silver catheters. Best method for autocorrelation?

Hip-rehab trial with large loss to follow-up in one arm. Most robust analysis?