Drug Discovery & Development
Authored by Syazwani Amran
Biology
University
Used 226+ times
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20 questions
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1.
MULTIPLE CHOICE QUESTION
20 sec • 1 pt
The first step in rational drug design is to ________
identify the target molecule
characterize the shape of the target molecule
find a lead
test the drug molecule
2.
MULTIPLE CHOICE QUESTION
20 sec • 1 pt
In rational drug design, you cannot design a new drug until _______
you have tested a similar drug on animals
you have tested a similar drug on people
you have characterized the structure of the target molecule
you have received clearance to do so from the FDA
3.
MULTIPLE CHOICE QUESTION
20 sec • 1 pt
The target molecules can be the following EXCEPT
receptors
enzymes
free oxygen
transcription factors
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of these statements best describes a lead compound?
A compound that contains the element lead
A molecule that shows some activity or property of interest and serves as the starting point for the development of a drug
A compound from the research laboratory that is chosen to go forward for preclinical and clinical trials
The first compound of a structural class of compounds to reach the market.
5.
MULTIPLE CHOICE QUESTION
20 sec • 1 pt
Identify the kind of interactions that are typically involved in binding a drug to the binding site of a protein.
predominantly van der Waals interactions
predominantly hydrophobic interactions
predominantly hydrogen bonds
a combination of all of the above
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following statements best describes an induced fit?
the process by which a binding site alters shape such that it is ready to accept a drug
the process by which a drug adopts the correct binding conformation before entering a binding site
the process by which binding of a drug to a binding site alters the shape of the binding site
the process by which a binding site alters the shape of the drug into the binding conformation before binding
7.
MULTIPLE CHOICE QUESTION
20 sec • 1 pt
Which of the following descriptions most accurately describes binding sites and binding regions?
a binding site is part of a binding region
a binding region is part of a binding site
a binding region is the same as a binding site
a binding region is on a drug whereas a binding site is on a macromolecular target
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