What statement regarding the clinical use of β-Blockers is false

Provide sympathetic nervous system activity

Treatment of essential hypertension

Suppression of cardiac dysrhytmias

Which statement regarding β1 cardio-selective Blockers is true

Ideal medication to treat essential hypertension because there is no vasodilatory effects on peripheral blood vessels

Poorly suited for asthma patients

Increases chronotropic effects, decrease dromotropic and inotropic

Increase myocardial oxygen demand and myocardial ischemia

Which statement regarding β blockers is False

Preoperative beta blocker should be held to maintain desirable drug effects and to avoid the risk of sympathetic nervous hyperactivity

The larger the dose of a cardioselective beta blocker the more likely it will become non-selective

Beta blockers are reversible and competitive antagonist

Chronic administration of beta blockers is associated with an increase in B-adrenergic receptors

Does propranolol have a drug interaction with local anesthetics? What happens?

Yes; Decrease in the clearance of local anesthetics

Yes; Increase in metabolism of local anesthetics

Yes; Decrease in metabolism of local anesthetics

What is a good dose of Esmolol prior to intubation, to blunt the laryngeal stimulation response?

Dont give Esmolol prior to intubation

Which of the following is NOT a contradiction to β blockade

Sinus or AV node dysfunction, heart block

Which statement regarding local anesthetics is false

Local anesthetics are weak acids

Local anesthetics produce a reversible conduction blockade along central and peripheral nerve pathways

An increase in concentration produces a increase blockade of sensory, motor and autonomic nerve

Local anesthetics cause a loss of sensation in a discrete region of the body

Resting membrane potential is determined by what?

Potassium concentration differential across nerve call membrane

amount of sodium channels along the nerve

Sodium permeability through ionized channels

size of the nerve determines resting membrane potential

What are the three chemical structures employed by local anesthestics

Benzene Ring; Ester or amide chain; Secondary or Tertiary amine

Lipophilic; Hydrophilic; Static chain

Extra cellular; inner cellular; ester amide bond

acid section; basic section; neutral section

What portion of the local anesthetic is needed to bind to the receptor? Which is needed to penetrate the nerve

Sodium link to amide group; Potassium link to benze ring

Ionic charged lipophilic; and non charge hydrophilic

Esmolol can be used in all of the following except

Long-term management of essential hypertension

Suppression of cardiac dysrhythmias

Which statement is false about Metoprolol?

β1 selective at higher dosage non-selective

Suited for COPD/ PVD pts due to the lack of β2 activity

Which of the following increases the potency and toxicity of local anesthetics

Increasing the alkyl substitution and lengthening the chain

Halogenating the local anesthetic

Shortening the amide or ester chain

Which of the following is not a susceptibility that local anesthetics depend on?

Position of fiber in nerve bund

Mr. Smith just had a epidural placed under ultrasound guidance and confirmed in right place; local anesthetic is injected into the catheter. He starts having a metallic taste in his mouth, feeling light headed, and dizzy. What has happened

Epidural is placed in the wrong location

Mr. Smith needs to grow a pair and stop whining

Ester local anesthetics produce more allergic reactions due to?

Plasma pseudocholinesterase prolonged metabolism

Local anesthetics do not cause allergic reactions

Who is more likely to experience local anesthetic toxicity

Elderly patient with appropriate dose reduction

If the CC/CNS toxicity ratio is low what does it imply?

A reduced safety margin for local anesthetic

Higher toxicity of Cardiovascular muscles versus nerves

Plasma concentration need to be lower than 20 μg/ml

Robert is a 42 year old male that has abused cocaine for 20 years what is an expected clinical coronary finding

Hypertension and coronary vasospams

Hypotension; peripheral vasoconstriction

Right sided heart failure with pulmonary vasoconstriction

Pharmacology 2 Local Anesthetics/ Sympatholytics

Authored by Andrew Gonzalez

Other Sciences

University

Used 52+ times

Pharmacology 2 Local Anesthetics/ Sympatholytics

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MULTIPLE CHOICE QUESTION

30 sec • 1 pt

The pre-ganglionic sympathetic nerve fibers release what at the automatic nerve bundle?

Substance P

acetylcholine

Norepinephrine

Calcium

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following is a non-selective alpha antagonist?

Yohimbine

Prazosin

Doxazocin

Phentolamine

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following medication has the highest/most effective β1 selectively?

Propranolol

Esmolol

Atenolol

Carvedilol

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Mr. Johnson is 85 years old and has BPH, he has not seen the doctor in 2 years recently he has issues with syncope due to orthostatic hypotension, which medication would he be taking?

Doxazosin

Propranolol

Phentolamine

PO Nitroglycerin

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Bobby is a brand new SRNA and did not know what phenylephrine was but flushed into a blown IV; what is the treatment medication to give?

Yohimbine

Tolazoline

Phenoxybenzamine

Phentolamine

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following is not a symptom of pheochromocytoma

Increase Blood pressure

Increase Anxiety

Decrease Heart Rate

Decrease Weight

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which of the following medication irreversibly binds to α1 and α2 receptors, and is used as a long term treatment of pheochromocytoma?

Terazosin

Tamsulosin

Phentolamine

Phenoxybenzamine

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Pharmacology 2 Local Anesthetics/ Sympatholytics

The pre-ganglionic sympathetic nerve fibers release what at the automatic nerve bundle?

Which of the following is a non-selective alpha antagonist?

Which of the following medication has the highest/most effective β1 selectively?

Mr. Johnson is 85 years old and has BPH, he has not seen the doctor in 2 years recently he has issues with syncope due to orthostatic hypotension, which medication would he be taking?

Bobby is a brand new SRNA and did not know what phenylephrine was but flushed into a blown IV; what is the treatment medication to give?

Which of the following is not a symptom of pheochromocytoma

Which of the following medication irreversibly binds to α1 and α2 receptors, and is used as a long term treatment of pheochromocytoma?

What statement regarding the clinical use of β-Blockers is false

Mrs. Jones suffers from severe asthma attacks and is hospitalized at least 3 times a month for severe wheezing which beta blocker should be prescribed for her to lower her blood pressure at home?

True or False propranolol decrease clearance of amide local anesthetics due to decreased hepatic blood flow & inhibition of liver metabolism

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