
Antibiotics
Presentation
•
Health Sciences
•
Professional Development
•
Hard
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38 Slides • 25 Questions
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Open Ended
Why is it important to use the correct antibiotic regimen when treating infectious diseases like syphilis?
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Fill in the Blanks
Type answer...
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Multiple Choice
Which penicillin is the drug of choice for syphilis, and why should it not be given intravenously?
Penicillin VK; it is not effective intravenously
Penicillin G Benzathine; it can cause death if given IV
Amoxicillin; it causes allergic reactions if given IV
Dicloxacillin; it is nephrotoxic if given IV
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Open Ended
Summarize the main strategies for managing patients with a penicillin allergy label according to the PEN-FAST clinical decision rule.
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Multiple Choice
Which of the following antibiotics does NOT have antipseudomonal activity?
Piperacillin–tazobactam
Cefepime
Cefoperazone–sulbactam
Ceftazidime
Amoxicillin–clavulanate
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Multiple Choice
Which antibiotic is most appropriate for a 42-year-old man with suspected leptospirosis who cannot tolerate doxycycline and penicillin is unavailable?
Penicillin V
Cefazolin
Cefuroxime
Ceftriaxone
Oral doxycycline with antiemetics
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Multiple Choice
Based on the antimicrobial activity chart, which antibiotic combination shows activity against both ESBL-producing organisms and Pseudomonas aeruginosa (MDR/XDR)?
Cefiderocol
Ceftaroline/Avibactam
Cefepime/Enmetazobactam
Meropenem/Vaborbactam
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Multiple Choice
Resistance to which drug requires further testing before using clindamycin?
Cotrimoxazole
Cefazolin
Cefuroxime
Erythromycin
All of the above
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Multiple Choice
What is the MOST likely cause of the patient's myoclonus and altered mental status after starting cefepime?
Ceftriaxone-associated encephalopathy
Azithromycin withdrawal
Cefepime-induced neurotoxicity
Uremic encephalopathy
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Multiple Choice
Based on the antibiotic spectrum chart, which antibiotics cover both MRSA and Pseudomonas?
Vancomycin and Piperacillin-tazobactam
Linezolid and Meropenem
Clindamycin and Gentamicin
Ceftazidime and Tigecycline
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Fill in the Blanks
Type answer...
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Multiple Choice
A 42-year-old woman with a UTI is not improving on azithromycin. What is the most appropriate next step in management?
Switch to Clarithromycin
Increase azithromycin dose
Switch to a Co-trimoxazole
Switch to doxycycline
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Multiple Choice
A 72-year-old woman with diabetes and UTI due to Enterobacter is sensitive to imipenem, colistin, and aztreonam-avibactam. Which is the best antibiotic to use?
Colistin
Aztreonam–Avibactam
Imipenem
Fosfomycin
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Multiple Choice
Which antibiotic is MOST likely responsible for the patient's symptoms of burning sensation while eating, discoloration of the tongue, and pallor?
Linezolid
Vancomycin
Ciprofloxacin
Amoxicillin
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Multiple Choice
What is the best next step in management for a patient with pan-sensitive E. coli urosepsis who is now conscious and afebrile after 4 days of meropenem?
Continue meropenem for 3 more days
Stop meropenem
Switch to oral ciprofloxacin
Ask for MIC values
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Multiple Choice
Based on the systematic review and meta-analysis, what is the approximate percentage risk reduction in recurrent UTIs with cranberry products?
10%
20%
32.5%
50%
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Multiple Choice
Before starting cotrimoxazole in a patient with no documented allergy history, what is the MOST important step?
Start cotrimoxazole routinely
Give a test dose of cotrimoxazole
Ask & document any past sulfa allergy
Admit and start as in-patient
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Multiple Choice
Which of the following are accepted indications to start antibiotics in acute sinusitis?
Persistent symptoms >10 days
Severe symptoms with fever >38–39°C and purulent discharge
“Double-worsening” after initial improvement
All of the above
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Multiple Choice
What is the MOST appropriate next step for a patient with Salmonella Typhi sensitive to ceftriaxone who is clinically improving but still has fever on day 5 of ceftriaxone?
Switch to meropenem
Add azithromycin
Change ceftriaxone to 1 g IV twice daily
Continue ceftriaxone or switch to appropriate oral step-down and counsel
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Multiple Choice
Which pattern of fever is characteristic of typhoid, as shown in the graph?
Remittent fever
Step ladder fever
Intermittent fever
Relapsing fever
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Fill in the Blanks
Type answer...
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Multiple Choice
Based on the data provided, which antibiotic regimen leads to a faster defervescence in typhoid fever: ceftriaxone alone or ceftriaxone with azithromycin?
Ceftriaxone alone
Ceftriaxone with azithromycin
Both are equally effective
Neither is effective
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Multiple Choice
Which bacteria should NOT be treated in a patient with positive GI PCR panel for Salmonella, Shigella, Campylobacter jejuni, Yersinia enterocolitica, and Shiga toxin–producing E. coli (STEC)?
Salmonella
Shigella
Campylobacter jejuni
Yersinia enterocolitica
Shiga toxin–producing E. coli (STEC)
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Multiple Choice
A 29-year-old woman is screened because her husband tested positive for syphilis. She has no symptoms, ulcers, rash, or neurological signs. VDRL is 1:4 and TPHA is positive. She has no penicillin allergy, and her last menstrual period was 45 days ago. Which penicillin regimen is most appropriate?
Penicillin V orally 14 days
Crystalline Penicillin IV × 14 days
Benzathine Penicillin G weekly × 3
No antibiotics needed
Benzylpenicillin IV × 10 days
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Open Ended
After completing the Antibiotic Master Course 2025, what is one area related to antibiotics or infectious diseases that you would like to learn more about or still have questions on?
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