CH5.8 Muscular System Diseases & Disorders

Improper use of muscles

Fatigue

Genetic mutation

Overuse

Complete loss of muscle function

Mild pain and tenderness

Muscle torn completely through

Noticeable loss of strength

Grade I – Mild strain

Grade II – Moderate strain

Grade III – Severe strain

Chronic muscle fatigue

Becker affects both skeletal and smooth muscle.

Duchenne completely lacks functional dystrophin, while Becker retains partial function.

Becker occurs only in females.

Duchenne involves mitochondrial defects rather than gene mutations.

It increases scar tissue formation for protection.

It promotes blood flow and collagen repair without overloading damaged fibers.

It prevents the muscle from regaining its previous length.

It accelerates inflammation to speed up healing.

Affected males pass the mutation directly to their sons.

Males express the disorder because they inherit only one X chromosome carrying the mutation.

Affected males pass the mutation directly to their sons.

Females cannot be carriers because they have two X chromosomes.

Encourage full physical rest to prevent strain.

Implement moderate, low-impact exercise with cardiac monitoring.

Begin intensive strength training to build muscle mass.

Discontinue all physical activity to avoid dystrophin breakdown.