

Hepatic Neoplasms
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Science
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University
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Medium
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Standards-aligned
Sophia Liu
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11 Slides • 13 Questions
1
SCORE 10/1
Sophia Liu PGY-2
By Sophia Liu
Hepatic Neoplasms
2
Case Presentation
60 yo M presents to clinic for an incidentally found hepatic lesion on CT. It is 3cm in segment 6 of the liver.
It was found following panscans from an MVC with no traumatic injuries.
3
Multiple Choice
Which segment of the liver is the lesion in?
Green superior
Yellow superior
Orange inferior
Purple anterior
4
-Cantlie line divides the liver into right and left, and lies along the middle hepatic vein (NOT falciform!)
-Horizontal plan divided by the portal vein
-Functionally independent segments
Couinard Classification of Hepatic Segments
5
Open Ended
What is the differential diagnosis for this hepatic neoplasm?
6
Open Ended
What questions about his history would you ask?
7
He denies any current symptoms.
His PMH only includes HTN, well controlled with one medication.
His last colonoscopy was 8 years ago, normal, and was told to follow up in 10 years. He has no known hx of hepatitis or cancer.
Denies any family history of cancer.
He denies smoking, drinking, IVDU, or any other drug use.
8
Open Ended
What are you looking for on physical exam?
9
On physical exam, he is obese with a BMI of 35.
It is otherwise unremarkable; he is in no acute distress, no abdominal distension, no ascites, no palpable masses, no blood on DRE, no caput medusae, etc.
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Open Ended
What labs would you like to get?
11
Calculates 3-month mortality from liver disease, traditionally used for liver transplants
Has variations to include other important factors like sodium levels (MELD-Na, MELD combined)
MELD score
Used to predict morality from cirrhosis, and grade severity of liver disease. Often used to predict outcomes from other major surgeries.
Child-Pugh score
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CLIP scoring
0 = 42.5 months 1 = 32.0 months
2 = 16.5 months 3 = 4.5 months
4 = 2.5 months 5-6 = 1 month
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All the labs are within normal limits, except AFP, which is 100.
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Open Ended
What is your leading differential diagnosis now?
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Multiple Select
What is the next appropriate diagnostic imaging?
MRI Abd/pel
Triple phase CT
CT PET
No further imaging needed
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Fill in the Blanks
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Li-Rads scoring is used for liver lesions in patients with cirrhosis, to predict likelihood that lesion is HCC given the features seen on CT
Arterial phase
Venous phase
Capsule enhancement
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Multiple Choice
Our patient has the classic triad of HCC features on CT scan, with early cirrhosis and fatty liver. No nodularity or portal hypertension. What is his Li-Rads score?
LR 2
LR 3
LR 4
LR 5
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20
Poll
How would you manage this patient's HCC?
Resection
Transplant
Biopsy
Observation
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Barcelona Clinic Liver Cancer (BCLC) staging
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Multiple Choice
What margins are needed for resection?
4 cm
3 cm
1 cm
0.5 cm
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Multiple Select
If this patient was a poor surgical candidate, what other treatment options are available?
Ablation
TACE
Radioembo with yttrium-90
Systemic chemotherapy
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Poll
How would you manage the patient moving forward post-operatively?
AFP and CT every 3-6 months for 2-3 years, then every 6 months afterwards
AFP and MRI every 3-6 months for 2-3 years, then every 6 months afterwards
AFP and CT every 6 months for 2 years, then fu PRN
AFP and CT every 6 months indefinitely
SCORE 10/1
Sophia Liu PGY-2
By Sophia Liu
Hepatic Neoplasms
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