2025 UMMP Sedative Hypnotics
Presentation
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Science
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University
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Practice Problem
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Easy
Elsa Mohamed
Used 3+ times
FREE Resource
45 Slides • 7 Questions
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Multiple Choice
Which of the following best explains the anxiolytic effect of benzodiazepines?
Stimulation of serotonin receptors
Inhibition of orexin signaling
Enhancement of GABA-A receptor activity
Antagonism of histamine H1 receptors
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Multiple Choice
Which benzodiazepine is commonly used for IV sedation due to its rapid onset and short duration of action?
A. Diazepam
B. Lorazepam
C. Midazolam
D. Clonazepam
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Multiple Choice
Which adverse effect is most associated with long-term benzodiazepine use in the elderly?
Cognitive impairment & risk of fall
SJS-TENS
Increased appetite & metabolic
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Multiple Choice
Why are barbiturates less commonly used today for anxiety or sleep disorders?
A. They are ineffective as sedatives
B. They lack oral bioavailability
C. They induce melatonin suppression
D. They have a narrow therapeutic window and high overdose risk
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Multiple Choice
Which of the following is true regarding Z-drugs such as zolpidem and zaleplon?
A. They are non-selective GABA-A agonists
B. They have a higher risk of dependence than benzodiazepines
C. They act selectively on the α1 subunit of GABA-A receptors
D. They block orexin receptors
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Drag and Drop
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Multiple Choice
What is the mechanism of action of suvorexant in treating insomnia?
A. Enhances serotonin signaling
B. Stimulates melatonin receptors
C. Blocks GABA-A chloride channels
D. Antagonizes orexin receptors
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diagnostics: EEG procedure
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Case Key Takeaways
Avoid BDZs & Z-drugs: Strongly discouraged by Beers Criteria for elderly patients.
The Risk: Worsens confusion and muscle weakness, heavily increasing fall risks.
Best 1st Step: Non-pharmacological approach (CBT-Insomnia + sleep hygiene).
Safer Alternatives: Melatonin agonists (Ramelteon) or orexin antagonists (Suvorexant).
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