

Tough ART
Presentation
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Science
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Professional Development
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Easy
Ben Appenheimer
Used 1+ times
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1 Slide • 1 Question
1
Multiple Choice
You are seeing a patient who is on TAF/FTC + raltegravir. They had fallen out of care and were spacing out their medication 2-3 days to make it last. Now their viral load is 25,000 and genotype shows resistance to raltegravir with a mutation Y143C. Prior mutations showed K103N. She does not tolerate boosting agents. What is the best option for treatment?
Dolutegravir + lamivudine
TAF/FTC/ bictegravir
TAF/FTC + BID dolutegravir
TAF/FTC + darunavir/ cobicistat
2
Maintains effectiveness against most raltegravir/elvitegravir mutations, dose BID
Q148 reduces susceptibility, especially with other mutations
Efficacy of dolutegravir
raltegravir = elvitegravir << dolutegravir = bictegravir
Barrier to resistance
You are seeing a patient who is on TAF/FTC + raltegravir. They had fallen out of care and were spacing out their medication 2-3 days to make it last. Now their viral load is 25,000 and genotype shows resistance to raltegravir with a mutation Y143C. Prior mutations showed K103N. She does not tolerate boosting agents. What is the best option for treatment?
Dolutegravir + lamivudine
TAF/FTC/ bictegravir
TAF/FTC + BID dolutegravir
TAF/FTC + darunavir/ cobicistat
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