CHEM206 week 3 tute
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Biology, Chemistry
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University
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Hard
Organization admin
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3 Slides • 12 Questions
1
2
Multiple Choice
Glycogen is PRIMARILY stored in which cells?
Liver and heart
Brain and heart
Liver and brain
Liver and skeletal muscle
3
Multiple Choice
Name the bond making up branches in glycogen
alpha-1,4-glycosidic bond
phosphodiester bond
alpha-1,6-glycosidic bonds
4
Multiple Choice
Glycogenesis is initiated by?
glucose
glycogenin
glucose-6-phosphate
UDP-glucose
5
Multiple Choice
Name the reactant and product of phosphoglucomutase
glucose-6-phosphate and glucose
glucose and glucose-6-phosphate
glucose and glucose-1-phosphate
glucose-6-phosphate and glucose-1-phosphate
6
Multiple Choice
What high energy compound is used to make UDP-Glucose?
Adenosine diphosphate (ADP)
Adenosine triphosphate (ATP)
Uridine diphosphate (UDP)
Uridine triphosphate (UTP)
7
Multiple Choice
Which cellular compartment glycogenesis occur?
matrix of mitocondria
cytoplasm
intermembrane space of mitochondria
8
Multiple Choice
What enzyme overcomes (fructose-6-phosphate + ATP------> fructose-1,6-bisphosphate + ADP ) in gluconeogenesis
hexokinase
phosphofructokinase
Fructose-1,6-bisphosphatase
phosphofructokinase and Fructose-1,6-bisphosphatase
9
Multiple Choice
The Cori cycle is involved in
the transport of pyruvate formed in muscle cells to the liver
the transport of pyruvate formed in the liver to muscle cells
the transport of lactate formed in the liver to muscle cells
the transport of lactate formed in the muscle cells to the liver
10
Multiple Choice
What does biotin carry? What enzyme in gluconeogenesis uses biotin?
Carbon Carrier. Pyruvate Carboxylase
Carbon Carrier. Pyruvate Dehydrogenase
ATP Carrier. Pyruvate Dehydrogenase
ATP Carrier. Pyruvate Carboxylase
11
Multiple Select
Hormonal signalling can lead to activation of glycogen breakdown by
Acting on the glycogen phosphorylase enzyme directly
Acting on the glycogen phosphorylase enzyme indirectly
by using allosteric activators
by covalent modification of enzymes
12
Open Ended
Deficiency Case study:
Children diagnosed with Fructose 1,6-Bisphosphatase deficiency typically have hepatomegaly and experience lethargy and muscle weakness. Below are some Laboratory test results:
Glucose 1.3 mmol/L (4.20-6.20 mmol/L)
lactic acid 10.6 mmol/L (0.7-2.1 mmol/L).
Explain how the symptoms and test results related to Fructose 1,6-Bisphosphatase deficiency
13
A scientist extracted and purified Fructose-1,6-Bisphosphatase enzyme from rat liver and ran some enzyme activity assays. Look at the results below and answer the following questions.
Briefly, summarise the results shown in Fig 1.
Discuss the activity of the Fructose 1,6-Bisphosphatase and the effect of AMP has on its activity.
14
Open Ended
Explain why did the scientist pick liver for the enzyme extraction?A scientist extracted and purified Fructose-1,6-Bisphosphatase enzyme from rat liver and ran some enzyme activity assays. Look at the results below and answer the following questions.
Explain why did the scientist pick liver for the enzyme extraction?
15
A scientist extracted and purified Fructose-1,6-Bisphosphatase enzyme from rat liver and ran some enzyme activity assays. Look at the results below and answer the following questions.
Briefly, summarise the results shown in Fig 1.
Discuss the activity of the Fructose 1,6-Bisphosphatase and the effect of AMP has on its activity.
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