​Types of Mutations

• ​DELETION (a base is lost)

• INSERTION (an extra base is inserted)

  • Deletion and insertion may cause what’s called a FRAMESHIFT, meaning the reading “frame” changes, changing the amino acid sequence.

• POINT MUTATION (one base is substituted for another)

• If a point mutation changes the amino acid, it’s called a MISSENSE mutation.

• If a point mutation does not change the amino acid, it’s called a SILENT mutation.

• If a point mutation changes the amino acid to a “stop,” it’s called a NONSENSE mutation.

​Group/Independent Practice