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​The single cell resolution is paving the way towards the molecular characterizations of every cell type in different contexts. The application of single cell genomics technologies has revolutionized the existing approach to explore an individual's immunity. Unfolding the functional diversity of immune cells and their coordinated reaction is key to understanding the immune system. Single cell transcriptomics technologies open up a high-dimensional assessment of the transcriptional state of immune cells and have been successfully used to discover novel immune cell types, reveal hematopoietic lineages, identify gene modules regulating immune responses, and analysis lymphocyte antigen receptor diversity.