nonlinear kinetics review for relearning 2022
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Specialty
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University
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Medium
Sandra Earle
Used 10+ times
FREE Resource
11 Slides • 7 Questions
1
2
Any system that requires energy and a carrier, enzyme, or receptor system that can be overwhelmed
Anything that follows Michealis-Menten
3
Open Ended
List any/all pkinetic systems that can be nonlinear
4
5
Multiple Choice
If a system follows linear kinetics, would you expect the Css,avg to increase when DR increases?
Yes
No
6
7
Multiple Choice
If a system follows linear kinetics, would you expect the AUC to decrease when Dose decreases?
Yes
No
8
9
Multiple Choice
If a system follows linear kinetics, would you expect the clearance to increase with increasing DR or Dose?
Yes
No
10
11
Multiple Select
How can you tell that CL is decreasing with increasing DR?
Css,avg will be increasing with increasing DR more than proportionally when given IV
Css,avg will be decreasing with increasing DR more than proportionally when given IV
t1/2 will be increasing as DR increases
12
13
Multiple Select
What could cause volume to change with increasing DR?
nonlinear plasma protein binding
nonlinear tissue protein binding
nonlinear renal clearance
nonlinear hepatic clearance
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16
Multiple Choice
What could cause bioavailability to change with increasing DR?
nonlinear plasma protein binding
nonlinear hepatic enzymes
nonlinear renal clearance
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