

Medicinal Chemistry
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Anjana Sharma
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1 Slide • 20 Questions
1
Medicinal Chemistry

2
Multiple Choice
Promethazine is synthesized form
Phenothiazines
Phthalide
Pyrimidine
Pyridine
3
Multiple Choice
Diphenylmethane is a starting material material for the synthesis of
Ranitidine
Diphenylhydramine
Doxylamine
Loratidine
4
Multiple Choice
Captopril is a
ACE inhibitor
Calcium channel blocker
Sodium Channel Blocker
None of the above
5
Multiple Choice
One of the following anti-hypertensive is a prodrug
Enalpril maleate
Losartan
Verapamil
Prazosin
6
Multiple Choice
The antihypertensive agent also useful topically to stimulate hair growth
Esmolol
Minoxidil
Losartan
Nifedipine
7
Multiple Choice
Quinidine belongs to
Class IV
Class Ia
Class Ib
Class Ib
8
Multiple Choice
The anti-arrhythmic drug with local anaesthetic actions
Verapamil
Procainamide
Disopyramide
Bretylium
9
Multiple Choice
Chemically, verapamil belongs to
Benzothiazepines
1,4- dihydropyridine
Phenylalkylamines
None of the above
10
Multiple Choice
Which one of the following is a class I A agent
Phenytoin
Flecianide
Procainamide
Both b & C
11
Multiple Choice
What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
Carcinogenesis
Apoptosis
Metastasis
Mutagenesis
12
Multiple Choice
The doxorubicin (Adriamycin) which is useful for many types of cancer. Which of the following is true about this agent?
It’s an anthracycline type of drug
It intercalates into DNA, inhibits Topo II, and forms reactive oxygen species (ROS)
It can cause myelosuppression and cardiotoxicity.
All of these
13
Multiple Choice
The vinca alkaloids are a useful type of anti-cancer agents. Which of the following is true about these agents?
They all function by targeting the microtubules (i.e. they are anti-mitotic agents).
Paclitaxel and docetaxel are examples of vinca alkaloids.
They do not cause myelosuppression or peripheral neuropathy
A and B.
14
Multiple Choice
Histamine plays an important role in initiating the body's immune response to the presence of foreign antigens & pathogens. A primary source of histamine released during inflammatory conditions are:
B cells
Mast cells
T lymphocytes
Presynaptic nerve terminals
15
Multiple Choice
Which of the following enzyme is essential for the conversion of histidine to histamine?
Histidine amylase
Histidine hydrolase
Histidine decarboxylase
Histidine phosphorylase
16
Multiple Choice
Which of the following histamine receptor increases the release of gastric acid?
H1 receptor
H2 receptor
H3 receptor
d) H4 receptor
17
Multiple Choice
Which of the following histamine receptor increases the release of gastric acid?
H1 receptor
H2 receptor
H3 receptor
d) H4 receptor
18
Multiple Choice
Which of the following enzyme is essential for the conversion of histidine to histamine?
Histidine amylase
Histidine hydrolase
Histidine decarboxylase
Histidine phosphorylase
19
Multiple Choice
To which class of compounds do adrenaline, noradrenaline and dopamine belong?
Phenethylamines
Diphenolethylamines
Catecholamines
Adrenergics
20
Multiple Choice
What is the main clinical use for β1-adrenoceptor antagonists?
Treatment of glaucoma
Treatment of hypertension
Treatment of asthma
Treatment of pain
21
Multiple Choice
Which microorganism has been associated with the appearance of ulcers?
Eschericia coli
Staphylococcus aureus
Enterococcus faecalis
Helicobacter pylori
Medicinal Chemistry

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