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Medicinal Chemistry

Medicinal Chemistry

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Anjana Sharma

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1 Slide • 20 Questions

1

Medicinal Chemistry

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2

Multiple Choice

Promethazine is synthesized form

1

Phenothiazines

2

Phthalide

3

Pyrimidine

4

Pyridine

3

Multiple Choice

Diphenylmethane is a starting material material for the synthesis of

1

Ranitidine

2

Diphenylhydramine

3

Doxylamine

4

Loratidine

4

Multiple Choice

Captopril is a

1

ACE inhibitor

2

Calcium channel blocker

3

Sodium Channel Blocker

4

None of the above

5

Multiple Choice

One of the following anti-hypertensive is a prodrug

1

Enalpril maleate

2

Losartan

3

Verapamil

4

Prazosin

6

Multiple Choice

The antihypertensive agent also useful topically to stimulate hair growth

1

Esmolol

2

Minoxidil

3

Losartan

4

Nifedipine

7

Multiple Choice

Quinidine belongs to

1

Class IV

2

Class Ia

3

Class Ib

4

Class Ib

8

Multiple Choice

The anti-arrhythmic drug with local anaesthetic actions

1

Verapamil

2

Procainamide

3

Disopyramide

4

Bretylium

9

Multiple Choice

Chemically, verapamil belongs to

1

Benzothiazepines

2

1,4- dihydropyridine

3

Phenylalkylamines

4

None of the above

10

Multiple Choice

Which one of the following is a class I A agent

1

Phenytoin

2

Flecianide

3

Procainamide

4

Both b & C

11

Multiple Choice

What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?

1

Carcinogenesis

2

Apoptosis

3

Metastasis

4

Mutagenesis

12

Multiple Choice

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The doxorubicin (Adriamycin) which is useful for many types of cancer. Which of the following is true about this agent?

1

It’s an anthracycline type of drug

2

It intercalates into DNA, inhibits Topo II, and forms reactive oxygen species (ROS)

3

It can cause myelosuppression and cardiotoxicity.

4

All of these

13

Multiple Choice

The vinca alkaloids are a useful type of anti-cancer agents. Which of the following is true about these agents?

1

They all function by targeting the microtubules (i.e. they are anti-mitotic agents).

2

Paclitaxel and docetaxel are examples of vinca alkaloids.

3

They do not cause myelosuppression or peripheral neuropathy

4

A and B.

14

Multiple Choice

Histamine plays an important role in initiating the body's immune response to the presence of foreign antigens & pathogens. A primary source of histamine released during inflammatory conditions are:

1

B cells

2

Mast cells

3

T lymphocytes

4

Presynaptic nerve terminals

15

Multiple Choice

Which of the following enzyme is essential for the conversion of histidine to histamine?

1

Histidine amylase

2

Histidine hydrolase

3

Histidine decarboxylase

4

Histidine phosphorylase

16

Multiple Choice

Which of the following histamine receptor increases the release of gastric acid?

1

H1 receptor

2

H2 receptor

3

H3 receptor

4

d) H4 receptor

17

Multiple Choice

Which of the following histamine receptor increases the release of gastric acid?

1

H1 receptor

2

H2 receptor

3

H3 receptor

4

d) H4 receptor

18

Multiple Choice

Which of the following enzyme is essential for the conversion of histidine to histamine?

1

Histidine amylase

2

Histidine hydrolase

3

Histidine decarboxylase

4

Histidine phosphorylase

19

Multiple Choice

To which class of compounds do adrenaline, noradrenaline and dopamine belong?

1

Phenethylamines

2

Diphenolethylamines

3

Catecholamines

4

Adrenergics

20

Multiple Choice

What is the main clinical use for β1-adrenoceptor antagonists?

1

Treatment of glaucoma

2

Treatment of hypertension

3

Treatment of asthma

4

Treatment of pain

21

Multiple Choice

Which microorganism has been associated with the appearance of ulcers?

1

Eschericia coli

2

Staphylococcus aureus

3

Enterococcus faecalis

4

Helicobacter pylori

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Medicinal Chemistry

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